Skip to main content

Table 4 Analysis of the progression of the circadian clock

From: A detailed map of coupled circadian clock and cell cycle with qualitative dynamics validation

Phase

Num. markers reachable/total

(A) Reachability of markers

 RORG

1/1

 SIRT1

1/1

 ARNTL-CLOCK

1/1

 PER-CRY

1/1

Phase

Num. markers reachable/total

(B) Reachability of phases

 RORG

1/1

 SIRT1

1/1

 ARNTL-CLOCK

1/1

 PER-CRY

1/1

Phase N (phase N − 1 disabled)

Num. markers reachable/total

(C) Reachability of phases with preceding phase disabled

 SIRT1 (RORG1)

1/1

 ARNTL-CLOCK (SIRT1)

1/1

 PER-CRY (ARNTL-CLOCK)

0/1

 RORG (PER-CRY)

1/1

  1. We tested whether each phase of the circadian clock could be reached from each precursor state, with or without its preceding phase disabled. Results are shown for the 16 precursor states containing either NAD+ or NMN. For the eight remaining precursor states rather containing NAM, no markers were reachable. For (B) and (C), the phase is reachable if at least one of its markers is reachable. (A) Reachability of the markers of each phase (control). (B) Reachability of each phase. (C) Reachability of each phase with its preceding phase disabled