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Table 5 Analysis of the progression of the cell cycle

From: A detailed map of coupled circadian clock and cell cycle with qualitative dynamics validation

Phase

Num. markers reachable/total

(A) Reachability of markers

 early G1

5/5

 late G1

2/2

 early S

1/1

 late S

1/1

 G2

4/4

 M

4/4 (3/4)

Phase

Num. markers reachable/total

(B) Reachability of phases

 early G1

5/5

 late G1

2/2

 early S

1/1

 late S

1/1

 G2

4/4

 M

4/4 (3/4)

Phase N (phase N − 1 disabled)

Num. markers reachable/total

(C) Reachability of phases with preceding phase disabled

 early G1 (M)

5/5

 late G1 (early G1)

0/2

 early S (late G1)

0/1

 late S (early S)

0/1

 G2 (late S)

4/4

 M (G2)

0/4

  1. We tested whether each phase of the cell cycle could be reached from each precursor state, with or without its preceding phase disabled. Results were the same for the 24 precursor states except for one marker of phase M, which was not reachable from the eight precursor states containing NAM (shown in parantheses). For (B) and (C), the phase is reachable if at least one of its markers is reachable. (A) Reachability of the markers of each phase (control). (B) Reachability of each phase. (C) Reachability of each phase with its preceding phase disabled