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Table 6 Identified mutations of entities of the circadian clock controlling the reachability of at least one phase marker of a cell cycle phase

From: A detailed map of coupled circadian clock and cell cycle with qualitative dynamics validation

Cell cycle phase

Circadian clock entity

Mutation

early G1

HSP90

LoF

late G1

HSP90

LoF

early S

none identified

late S

HSP90

LoF

G2

PER:CRY:CSNK1:CLOCK:ARNTL

GoF

 

MYC:MIZ1

GoF

 

WEE1

LoF

 

ARNTL

LoF

 

CLOCK

LoF

 

CSNK2A

LoF

 

MIZ1

LoF

 

NAD+

LoF

 

PARP1

LoF

 

NR1D1

GoF

 

NMN*

LoF

 

NMNAT*

LoF

M

all controls of G2 and

 

CCNB1:CDK1

LoF

  1. Mutations either disable an entity (LoF), or force its activity (GoF) *: only in the eight precursor states containing NMN. For G2 and M: no mutations predicted for the eight precursor states containing NAM