Fig. 5
From: Estimating colocalization probability from limited summary statistics
a Heat map of tissue enrichments for select traits with the largest enrichments. Brighter blue indicates more significant enrichment. CAD, coronary artery disease; ad id scoliosis, adolescent idiopathic scoliosis; granulocyte %, granulocyte percentage of myeloid white cells; monocyte %, monocyte percentage of leukocytes. b Average tissue-trait similarity for enriched pairs by enrichment \(p\)-value. Similarities are computed from cooccurance in PubMed articles. c Odds ratio of a gene-trait pair matching an approved drug mechanism by eQTL \(p\)-value of the GWAS top SNP and colocalization posterior probability P(\({\mathrm{H}}_{4}\)) (red dot). Odds ratios are computed relative to cis gene-trait pairs with both eQTL \(p\)-value \(>{10}^{-6}\) and colocalization posterior probability less than 0.9. Boxplots show the distribution of this odds ratio using permuted GWAS trait labels