Fig. 4

Module 7 network comparison between young and old. a Module 7 GCN graph plotted with GWENA (0.95 co-expression score filter) for young age range with sub-clusters detected. b Same as a but for the old age range. A zoom is made on sub-module 4 to show the peripheral genes disconnection. The new sub-module 6 is visible in purple in the old graph. c Difference network heatmap (old–young) ordered according to young age range network dendrogram. Sub-modules from old age range are visible on the top of the heatmap in columns, and sub-modules from young age range on the right in rows. Three zooms are made on the heatmap on the areas corresponding to sub-module 6 genes. Zoom ① contains the genes reconnecting in the old age range