Table 1 C. burnetii isolates chosen for proteome-wide comparison

Nine Mile Phase I

(RSA 493)

I

Tick

(United States)

Minimalistic Genome

Acute

[35, 36, 38, 39]

Ohio 314

(RSA 270)

I

Cow Milk

(United States)

Cow Isolate Causing Human Disease

Chronic

[36, 39]

Z3055

II-a

Sheep Placenta (Germany)

Netherlands Outbreak of 2007–2010, Non-synonymous Gene Mutations of Membrane Proteins

Acute

[40, 41]

Henzerling

II-b

Human Blood

(Italy)

Q-vax Strain

Acute

[36, 39, 40]

701CbB1

III

Cattle (France)

Human PBMC Exposure Causes Similar Cytokine Profile to C. burnetii Responsible for Acute Disease

Unknown

[40, 42]

Q545

III

Cattle Abortion

(UK)

Type MST20, Common MST in Cow Milk of United States

Unknown

[37, 42, 43]

MSU Goat Q177

IV

Goat Cotyledon (United States)

Putative Ancestral Genotype of Group IV

Chronic

[12, 35, 39, 44]

Schperling

IV

Human Blood

Acute

[37, 40]

CbuG_Q212

V

Heart Valve

(Nova Scotia)

Integrated/Chromosomal Plasmid

Chronic

[35, 36, 41]

Dugway 5J108-111

VI

Rodent

(United States)

Largest Genome

Avirulent

[35, 39, 41]