Proteome-wide analysis of Coxiella burnetii for conserved T-cell epitopes with presentation across multiple host species

Table 3 Human MHCII epitopes with presentation by an exceptional range of host alleles

Pos	GenBank ID	Peptide	NB	WB	SB	Gene Name	Locus Tag	Location
226	AAO89704.2	EGAIRHTHVIPIAGD	206	25	181	ftsA	CBU_0140	CYTOPLASM(non-PSE)
259	AAO89704.2	QIKIKYASVLPEEVN	206	28	178	ftsA	CBU_0140	CYTOPLASM(non-PSE)
9	AAO90441.1	DKEIRAISDYVVNHK	206	35	171	*prpD*	CBU_0912	CYTOPLASM(non-PSE)
567	AAO90965.2	QLRIVASHANISGNP	206	74	132		CBU_1468	PSE-Membrane
169	AAO90977.1	RQSIRYYHTAAAIKN	206	10	196		CBU_1480	PSE-Membrane
390	AAO91005.1	RGKFKIYIADPAIAP	206	82	124		CBU_1508	CYTOPLASM(non-PSE)
678	AAO91357.1	GNKIIQIAPARVANR	206	53	153	parC	CBU_1866	CYTOPLASM(non-PSE)
403	AAO91392.1	RQNIRAVDTQQVTAA	206	65	141		CBU_1901	SECRETED
329	AAO91494.1	NNAIRYAKNVNVRIQ	206	49	157	rstB	CBU_2005	PSE-Membrane
205	AAO91497.1	QGEYIIDIAEALKAK	206	61	145	argS	CBU_2008	CYTOPLASM(non-PSE)

Pos indicates the peptide/epitope starting position within the protein sequence. GenBank IDs, gene names, and locus tags are the assembly annotations given on NCBI. NB, WB, and SB represent the total number of alleles bound, the number of alleles bound weakly, and the number of alleles bound strongly by the indicated peptide respectively. Location of the proteins was assigned based on Inmembrane, where PSE designates potentially surface exposed proteins. The bolded row indicates the protein not represented in the murine data when filtering for epitopes binding 100% of alleles tested

ISSN: 1471-2105