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Fig. 2 | BMC Bioinformatics

Fig. 2

From: A comprehensive database for integrated analysis of omics data in autoimmune diseases

Fig. 2

Overview of the ADEx application and analysis of IFN signature across diseases. a ADEx has six main sections. Section 1 provides information about available datasets. In Section 2, users can explore expression and methylation for individual genes. Section 3 implements a module to explore data for a gene list, such as gene module or genes from a biological pathway, across several datasets. Section 4 allows researchers to perform analysis on individual datasets retrieving differential expression signatures and pathways and cell signaling enrichment analyses. Section 5 implements meta-analysis methods to integrate multiple datasets in order to define common biomarkers. Section 6 is for data download. b Gene Set Query section screenshot. Datasets and gene set input is shown. Users select data there to plot a heatmap. c IFN signature expression generally separates SLE and SjS from other ADs. Heatmap with the IFN genes generated in ADEx. Color represents the log2 FC of disease versus healthy samples (red for overexpression and blue for underexpression)

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