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Fig. 10 | BMC Bioinformatics

Fig. 10

From: PhyliCS: a Python library to explore scCNA data and quantify spatial tumor heterogeneity

Fig. 10

Test case: MDA-MB-231 cell line data. We tested PhyliCS on MDA-MB-231 cell line. In details, we compared the parental cell-line the the datasets resulting from the clonal expansion of two dauther cells, MDA-MB-231-EX1 and MDA-MB-231-EX2, for 19 doublings. The datasets contain 508, 995 and 897 cells respectively. We obtained the evidence that the dataset deriving from the expansion of MDA-MB-231-EX1 was more similar to the parental line, with respect to the genomic profile of the data deriving from MDA-MB-231-EX2 (a). In fact, the best SHscore (0.7102) was obtained when aggregating MDA-MB-231-EX1 dataset with the parental against the other one (b)

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