Fig. 3
From: PhyliCS: a Python library to explore scCNA data and quantify spatial tumor heterogeneity
Spatial subclonal segregation and intermixing simulation. We generated 50 phylogenetic trees (a) made of 2500 cells. For each tree we simulatated: (I) early segregation of subclones (hom) by tracking the progeny of the first five generated cells and assigned the leaves to five distinct subsamples, corresponding to the five subclones (b); (II) spatial intermixing of subclones (het) by shuffling the leaves and assigning them randomly to five subsamples (c)