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Fig. 7 | BMC Bioinformatics

Fig. 7

From: PhyliCS: a Python library to explore scCNA data and quantify spatial tumor heterogeneity

Fig. 7

SHscore versus evolutionary distance. We executed a Pearson correlation test on the SHscores and the MRCA distances, demonstrating that the two quantities are positively correlated (coef = 0.628, p value = 1e−11) (a). We aggregated the SHscores computed on datasets deriving from from trees which growth was stopped at a different height. The scores in the three scenarios are distributed around a different median (2.5 K cells = median: 0.151, IQR: 0.064, 10 K cells = median: 0.278, IQR: 0.061, 100 K cells = median: 0.498, IQR: 0.092), which value increases as the mean distance between the MRCAs of the sample increases (b)

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