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Table 1 The number of n-controller metabolite interactions that exist in or are possible for each model

From: SCOUR: a stepwise machine learning framework for predicting metabolite-dependent regulatory interactions

 

Smaller synthetic model

Bigger synthetic model

S. cerevisiae

E. coli

# of 1-controller interactions

1

3

5

25

# of possible 1-controller interactions

5

9

12

39

# of 2-controller interactions

2

3

10

13

# of possible 2-controller interactions

20 (25)

54 (81)

157 (262)

243 (668)

# of 3-controller interactions

2

3

5

2

# of possible 3-controller interactions

20 (50)

108 (324)

520 (2720)

336 (5384)

# of 4-controller interactions

N/A

N/A

2

4

# of possible 4-controller interactions

N/A

N/A

380 (17,860)

480 (27,120)

  1. For possible interactions, the first number assumes that regulatory interactions are correctly identified at each step of the framework and are removed from consideration for higher-order interactions. The number in parentheses is the total number of possible interactions if a stepwise framework were not used, illustrating the significant decrease in the number of interactions to be assessed in a stepwise framework