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Table 5 The intersection of the first 10 pathways (sorted by the relevance of p value \(\le 0.005\)) obtained from BiP by performing PEA using EC genes lists and the KEGG database

From: Using BioPAX-Parser (BiP) to enrich lists of genes or proteins with pathway data

Pathway Name

p value

FDRc

Bc

(1) Metabolic pathways

1.18 × 10\(^{-199}\)

3.21 × 10\(^{-197}\)

3.21 × 10\(^{-197}\)

(2) Cytokine-cytokine receptor interaction

3.14 × 10\(^{-84}\)

4.27 × 10\(^{-82}\)

8.53 × 10\(^{-82}\)

(3) Pathways in cancer

1.12 × 10\(^{-49}\)

1.01 × 10\(^{-47}\)

3.04 × 10\(^{-47}\)

(4) Neuroactive ligand-receptor interaction

5.60 × 10\(^{-36}\)

3.81 × 10\(^{-34}\)

1.52 × 10\(^{-33}\)

(5) Pathways of neurodegeneration-multiple diseases

2.09 × 10\(^{-33}\)

1.14 × 10\(^{-31}\)

5.69 × 10\(^{-31}\)

(6) Transcriptional misregulation in cancer

7.91 × 10\(^{-33}\)

3.59 × 10\(^{-31}\)

2.15 × 10\(^{-30}\)

(7) MAPK signaling pathway

4.41 × 10\(^{-31}\)

1.71 × 10\(^{-29}\)

1.20 × 10\(^{-28}\)

(8) NOD-like receptor signaling pathway

2.64 × 10\(^{-28}\)

8.98 × 10\(^{-27}\)

7.18 × 10\(^{-26}\)

(9) Shigellosis

9.48 × 10\(^{-28}\)

2.86 × 10\(^{-26}\)

2.58 × 10\(^{-25}\)

(10) Proteoglycans in cancer

1.94 × 10\(^{-27}\)

5.29 × 10\(^{-26}\)

5.29 × 10\(^{-25}\)

  1. In the table, FDRc represents the corrected p value using FDR corrector, and Bc refers to the corrected p value using Bonferroni corrector