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Table 8 The intersection of the first 10 pathways (sorted by the relevance of p value \(\le 0.005\)) obtained from BiP, performing PEA using TC genes lists and the KEGG database

From: Using BioPAX-Parser (BiP) to enrich lists of genes or proteins with pathway data

Pathway Name

p value

FDRc

Bc

(1) Metabolic pathways

1.59 × 10\(^{-111}\)

4.98 × 10\(^{-109}\)

4.98 × 10\(^{-109}\)

(2) Cytokine-cytokine receptor interaction

1.02 × 10\(^{-40}\)

1.60 × 10\(^{-38}\)

3.21 × 10\(^{-38}\)

(3) Pathways in cancer

2.50 × 10\(^{-30}\)

2.62 × 10\(^{-28}\)

7.85 × 10\(^{-28}\)

(4) Pathways of neurodegeneration-multiple diseases

7.56 × 10\(^{-26}\)

5.93 × 10\(^{-24}\)

2.37 × 10\(^{-23}\)

(5) Ubiquitin mediated proteolysis

1.75 × 10\(^{-17}\)

3.44 × 10\(^{-16}\)

5.50 × 10\(^{-15}\)

(6) Neuroactive ligand-receptor interaction

2.72 × 10\(^{-17}\)

4.75 × 10\(^{-16}\)

8.56 × 10\(^{-15}\)

(7) Oxidative phosphorylation

7.94 × 10\(^{-17}\)

1.25 × 10\(^{-15}\)

2.49 × 10\(^{-14}\)

(8) Ribosome

2.02 × 10\(^{-16}\)

2.89 × 10\(^{-15}\)

6.35 × 10\(^{-14}\)

(9) Protein processing in endoplasmic reticulum

1.39 × 10\(^{-15}\)

1.62 × 10\(^{-14}\)

4.37 × 10\(^{-13}\)

(10) Human immunodeficiency virus 1 infection

2.06 × 10\(^{-15}\)

2.16 × 10\(^{-14}\)

6.47 × 10\(^{-13}\)

  1. In the table, FDRc represents the corrected p value using FDR corrector, and Bc refers to the corrected p value using Bonferroni corrector