Table 2 Case studies for the top predictions in DS1
From: AttentionDDI: Siamese attention-based deep learning method for drug–drug interaction predictions
Rank | ID A | ID B | Drug A | Drug B | Interaction |
|---|---|---|---|---|---|
1 | DB01194 | DB00273 | Brinzolamide | Topiramate | The risk or severity of adverse effects can be increased when Topiramate is combined with Brinzolamide |
2 | DB01589 | DB00678 | Quazepam | Losartan | The metabolism of Quazepam can be decreased when combined with Losartan |
3 | DB01212 | DB00417 | Ceftriaxone | PenicillinV | No interactions |
4 | DB01586 | DB00951 | Ursodeoxycholicacid | Isoniazid | No interactions |
5 | DB01337 | DB00565 | Pancuronium | Cisatracurium | Pancuronium may increase the central nervous system depressant (CNS depressant) activities of Cisatracurium |
6 | DB00351 | DB00484 | Megestrolacetate | Brimonidine | No interactions |
7 | DB00530 | DB00445 | Erlotinib | Epirubicin | No interactions |
8 | DB00458 | DB00659 | Imipramine | Acamprosate | No interactions |
9 | DB01586 | DB00319 | Ursodeoxycholicacid | Piperacillin | No interactions |
10 | DB00443 | DB00333 | Betamethasone | Methadone | The metabolism of Methadone can be increased when combined with Betamethasone |
11 | DB00458 | DB00321 | Imipramine | Amitriptyline | The metabolism of Amitriptyline can be decreased when combined with Imipramine |
12 | DB00790 | DB00584 | Perindopril | Enalapril | The risk or severity of angioedema can be increased when Enalapril is combined with Perindopril |
13 | DB01059 | DB00448 | Norfloxacin | Lansoprazole | No interactions |
14 | DB00571 | DB01203 | Propranolol | Nadolol | Propranolol may increase the arrhythmogenic activities of Nadolol |
15 | DB00975 | DB00627 | Dipyridamole | Niacin | No interactions |
16 | DB00967 | DB01173 | Desloratadine | Orphenadrine | Desloratadine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine |
17 | DB00222 | DB00328 | Glimepiride | Indomethacin | The protein binding of Glimepiride can be decreased when combined with Indomethacin |
18 | DB00193 | DB01183 | Tramadol | Naloxone | The metabolism of Naloxone can be decreased when combined with Tramadol |
19 | DB00904 | DB00918 | Ondansetron | Almotriptan | The risk or severity of adverse effects can be increased when Ondansetron is combined with Almotriptan |
20 | DB00423 | DB00794 | Methocarbamol | Primidone | The risk or severity of adverse effects can be increased when Methocarbamol is combined with Primidone |