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Table 2 Case studies for the top predictions in DS1

From: AttentionDDI: Siamese attention-based deep learning method for drug–drug interaction predictions

Rank ID A ID B Drug A Drug B Interaction
1 DB01194 DB00273 Brinzolamide Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Brinzolamide
2 DB01589 DB00678 Quazepam Losartan The metabolism of Quazepam can be decreased when combined with Losartan
3 DB01212 DB00417 Ceftriaxone PenicillinV No interactions
4 DB01586 DB00951 Ursodeoxycholicacid Isoniazid No interactions
5 DB01337 DB00565 Pancuronium Cisatracurium Pancuronium may increase the central nervous system depressant (CNS depressant) activities of Cisatracurium
6 DB00351 DB00484 Megestrolacetate Brimonidine No interactions
7 DB00530 DB00445 Erlotinib Epirubicin No interactions
8 DB00458 DB00659 Imipramine Acamprosate No interactions
9 DB01586 DB00319 Ursodeoxycholicacid Piperacillin No interactions
10 DB00443 DB00333 Betamethasone Methadone The metabolism of Methadone can be increased when combined with Betamethasone
11 DB00458 DB00321 Imipramine Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Imipramine
12 DB00790 DB00584 Perindopril Enalapril The risk or severity of angioedema can be increased when Enalapril is combined with Perindopril
13 DB01059 DB00448 Norfloxacin Lansoprazole No interactions
14 DB00571 DB01203 Propranolol Nadolol Propranolol may increase the arrhythmogenic activities of Nadolol
15 DB00975 DB00627 Dipyridamole Niacin No interactions
16 DB00967 DB01173 Desloratadine Orphenadrine Desloratadine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine
17 DB00222 DB00328 Glimepiride Indomethacin The protein binding of Glimepiride can be decreased when combined with Indomethacin
18 DB00193 DB01183 Tramadol Naloxone The metabolism of Naloxone can be decreased when combined with Tramadol
19 DB00904 DB00918 Ondansetron Almotriptan The risk or severity of adverse effects can be increased when Ondansetron is combined with Almotriptan
20 DB00423 DB00794 Methocarbamol Primidone The risk or severity of adverse effects can be increased when Methocarbamol is combined with Primidone
  1. Interaction information from the DrugBank database