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Table 5 The novel interactions predicted by DTI-HeNE and corresponding evidence provided by external databases

From: DTI-HeNE: a novel method for drug-target interaction prediction based on heterogeneous network embedding

Drug ID

Drug names

Target ID

Target names

Evidence sources

Enzymes

    

D00437

Nifedipine

hsa1585

CYP11B2

M, CTD

D00528

Caffeine

hsa50940

PDE11A

CTD

D00126

Ibuprofen

hsa247

ALOX15B

M

D00394

Trimipramine

hsa5152

PDE9A

None

D00574

Aminoglutethimide

hsa1589

CYP21A2

M

G-protein-coupled receptors

    

D00513

Pindolol

hsa152

ADRA2C

None

D01713

Epinastine

hsa152

ADRA2C

C

D00454

Olanzapine

hsa3357

HTR2B

K, T, CTD

D02354

Thiethylperazine

hsa1816

DRD5

C

D00283

Clozapine

hsa1132

CHRM4

D, C, T

Ion channels

    

D00524

Carbachol

hsa1138

CHRNA5

CTD

D03365

Nicotine

hsa1138

CHRNA5

K, D, T, CTD

D03826

Physostigmine sulfate

hsa2564

GABRE

None

D00550

Midazolam

hsa2570

GABRR2

T, CTD

D00303

Disopyramide

hsa6326

SCN2A

K

Nuclear receptors

    

D00585

Mifepristone

hsa2099

ESR1

M, T, CTD

D00066

Progesterone

hsa2100

ESR2

D, CTD

D01161

Fulvestrant

hsa5241

PGR

M, C

D00182

Norethisterone

hsa2099

ESR1

CTD

D00066

Progesterone

hsa367

AR

DB, CTD

DrugBank

    

DB01589

Quazepam

P47870

GABRB2

T, K

DB00546

Adinazolam

Q16445

GABRA6

K

DB00321

Amitriptyline

P14416

DRD2

T

DB01215

Estazolam

Q16445

GABRA6

K

DB00696

Ergotamine

P41595

HTR2B

D, C, T