Fig. 1

Schematic representation of combining single-cell and bulk sequencing data for clonal tree inference in Conifer method, a \(n \times m\) matrix in which each row and column represents SNVs and cell, respectively. White elements show no mutation and blue ones show mutation has occurred. 1 and 0 with the red font show false-positive and false-negative (drop-out events), respectively, b \(n \times b\) matrix that its rows are SNVs and its columns are bulk samples and \(B_{ij}\) is variant allele frequency in bulk samples, c co-occurred patterns of SNVs in single-cell profiles which are determined by dashed rectangles, d the inferred clonal tree and cell attachment