Fig. 4
From: Conifer: clonal tree inference for tumor heterogeneity with single-cell and bulk sequencing data
Comparison of co-clustering accuracy in OncoNEM and Conifer models for 100 clonal trees simulated with 20 clones and 100 mutations and for \(\lambda\) = 1, 5, 10 and 1000. For single-cell data 25, 50, and 100 genotypes are extracted for each clonal tree. There is one bulk sequencing sample with a coverage of 10,000. The following errors are added to the single-cell data: the false-positive rate of 10–5, the false-negative rate of 0.2, the missing rate of 0.05, and the doublet rate of 0.1