Fig. 3

Scatter plots of centrality metrics distributions showing significant differences between Phase4 targets and all targets (a–d). Three-dimensional plot of average shortest path vs. degree vs. topological coefficient (a), and pairwise two-dimensional projections with logarithmic scaling (b–d). Red lines and values indicate approximate parameter boundaries enclosing most Phase4 targets. e and f Examples of local network connectivity of Phase4 and all targets kinases with different degrees, average shortest path and topological coefficient. The Phase4 kinase JAK1 is more central within its local network than GRK6