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Table 13 Analysis of Gene Ontology (GO) terms enrichment in ‘Phase4’ versus ‘all targets’ protein sets

From: Centrality of drug targets in protein networks

  1. The most frequent GO terms (representing 95% of all GO associations for the proteins in the String07 database) were ranked based on total number of associations. GO terms that exhibit twofold higher or lower frequency within the Phase4 set compared to the ‘all targets’ set are highlighted in blue or red respectively. In the target class specific analysis (right side of the table), the normalized difference in frequency of each term is reported. Values with effect size resulting in > 0.8 statistical power (p = 0.05) for the sample size of each dataset are highlighted in bold fonts