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Table 7 Correlation between enrichment in citations and probability of differences in centrality metrics between Phase4 targets and all targets class (not corrected for multiple testing)

From: Centrality of drug targets in protein networks

Network String 0.7 String 0.9 String 0.5 Biogrid HumanNet XN Reactome InBioMap
Shortest path Degree Topol. coeff Shortest path Degree Topol. coeff Shortest path Degree Topol. coeff Shortest path Degree Topol. coeff Shortest path Degree Topol. coeff Shortest path Degree Topol. coeff Shortest path Degree Topol. coeff
Adjusted R 0.30 0.30 0.50  − 0.02  − 0.09  − 0.05 0.58 0.38 0.69  − 0.11 0.34 0.54  − 0.06 0.15 0.004  − 0.24  − 0.23 0.06  − 0.20 0.26  − 0.16
P 0.15 0.15 0.07 0.40 0.49 0.43 0.05 0.11 0.03 0.51 0.13 0.06 0.46 0.24 0.37 0.90 0.81 0.65 0.69 0.17 0.61
  1. Significant correlations are marked in bold (α = 0.05)