Fig. 2

Benchmarking and comparison of KinOrtho with other methods. a Evaluations of the kinase orthologs identified by KinOrtho (marked in red) and 21 other methods. The title of each plot represents the evaluation metric. The dotted line represents the Pareto frontier, which runs over the participants with the best efficiency (except KinOrtho). The arrow in the plot shows the optimal corner. Red square: KinOrtho full-length set; red diamond: KinOrtho domain-based set; red triangle: KinOrtho overlapping set. b The 100% stacked bar chart shows the overlap in kinase orthologs identified by KinOrtho versus other orthology inference methods (blue region); a dashed line indicates the average percentage of the overlaps (KinOrtho Full-length and KinOrtho Domain-based do not count). The orange region represents the percentage of orthologs only identified by KinOrtho; a dotted line indicates the average percentage of the blue and orange regions. The gray region shows the percentage of orthologs unique to the compared method. c The heat map represents the Jaccard similarity matrix among orthology inference methods. Method indices are shown on the left and top of the matrix