Table 1 GO term enrichment analysis on the phylogenetic clusters of human kinases

2

27128

Eukaryota

GO:0000075 (cell cycle checkpoint)

4765

3619

3.66

< 1.0E−320

GO:0098805 (Whole membrane)

1289

890

3.33

2.3E−306

GO:0046488 (Phosphatidylinositol metabolic process)

2634

1772

3.24

< 1.0E−320

3

16899

Vertebrata

Protostomia (partial)

Fungi

GO:0000165 (MAPK cascade)

1943

1025

4.08

< 1.0E−320

GO:0005694 (Chromosome)

284

120

3.27

< 1.0E−320

GO:1902749 (Regulation of cell cycle G2/M phase transition)

983

380

2.99

2.2E−10

4

6933

Vertebrata

Protostomia (partial)

Plants

GO:0010468 (Regulation of gene expression)

9690

796

1.55

< 1.0E−320

GO:0006807 (Nitrogen compound metabolic process)

20390

1470

1.36

< 1.0E−320

GO:0044238 (Primary metabolic process)

23630

1663

1.33

2.1E−09

5

12496

Metazoa

GO:0008047 (Enzyme activator activity)

778

341

4.59

1.9E−10

GO:0090287 (Regulation of cellular response to growth factor stimulus)

627

249

4.15

3.7E−11

GO:0016055 (Wnt signaling pathway)

415

161

4.06

< 1.0E−320

6

16115

Vertebrata

Protostomia (partial)

GO:0045669 (Positive regulation of osteoblast differentiation)

437

243

4.51

1.1E−102

GO:0030500 (Regulation of bone mineralization)

508

244

3.90

< 1.0E−320

GO:0034645 (Cellular macromolecule biosynthetic process)

797

330

3.36

1.0E−10

7

17842

Vertebrata

GO:0042629 (Mast cell granule)

54

54

7.33

5.5E−46

GO:0030522 (Intracellular receptor signaling pathway)

152

146

7.04

8.6E−116

GO:0042102 (Positive regulation of T cell proliferation)

211

202

7.01

1.6E−159

8

10994

Mammals

Reptiles/Birds (partial)

Fish

GO:0051965 (Positive regulation of synapse assembly)

250

177

8.42

2.2E−128

GO:0005004 (GPI-linked ephrin receptor activity)

215

130

7.19

5.4E−81

GO:0005005 (Transmembrane-ephrin receptor activity)

267

143

6.37

3.9E−79

9

10202

Mammals

Reptiles/Birds (partial)

GO:0001669 (Acrosomal vesicle)

103

75

9.33

3.2E−58

GO:0031253 (Cell projection membrane)

283

161

7.29

1.8E−99

GO:0014068 (Positive regulation of phosphatidylinositol 3-kinase signaling)

413

164

5.09

4.8E−11

10

3043

Mammals (partial)

GO:0035173 (Histone kinase activity)

665

96

6.20

1.1E−11

GO:0050321 (Tau-protein kinase activity)

318

43

5.81

8.7E−12

GO:0051051 (Negative regulation of transport)

818

98

5.15

< 1.0E−320