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Fig. 5 | BMC Bioinformatics

Fig. 5

From: Constructing xenobiotic maps of metabolism to predict enzymes catalyzing metabolites capable of binding to DNA

Fig. 5

Filtered map of metabolism for caffeine. a Production probability score of predicted metabolites. The production probability score of each metabolite is computed according to a Bayesian model based on the reaction production probability scores. Red, green and blue bars are associated with caffeine, known and unknown metabolites, respectively. Metabolites are grouped into three groups according to their range of scores (black, red and yellow ellipses). b Filtered map of metabolism of caffeine. This map is the filtration of the previous predicted map in order to keep metabolites with a high production probability score (black ellipse, score > 0.70). The map contains 13 metabolites and 17 reactions. Two unknown metabolites (nodes 9 and 11) are predicted to be nearly as likely to be produced as the known metabolites according to the production probability scores. Each (a) and (b) figure are available in a plain page format in Additional file 4

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