Fig. 4

Network-based metabolic models incorporating resource allocation (RA). RA models were classified into predictive and descriptive models. Predictive RA models include coarse-grained models that incorporating phenomenological constraints of macromolecular expressions and fine-grained models that integrate metabolic models with detailed matrices of macromolecular expression processes. Descriptive models are EFMA-based RA models that investigate resource allocation phenomena through converting the metabolic network into EFMs and combining EFMs with macromolecular expression information