Spatial rank-based multifactor dimensionality reduction to detect gene–gene interactions for multivariate phenotypes

Table 3 Hit ratios of MR-MDR according to the noise distance δ (r = 0.25, n = 200)

Distribution	Heritability	\(\delta\)= 1.5		\(\delta\)= 2		\(\delta\)= 2.5		Iterative \(\delta\) (default)
Distribution	Heritability	Hit ratio	Noise (%)	Hit ratio	Noise (%)	Hit ratio	Noise (%)	Hit ratio	Noise (%)
Bivariate	0.01	0.004	14.78	0.007	5.10	0.005	1.27	0.009	12.02
Normal	0.025	0.003	14.78	0.008	4.96	0.007	1.16	0.006	11.90
	0.05	0.024	14.79	0.026	5.04	0.038	1.19	0.041	11.92
	0.1	0.073	14.54	0.1	4.86	0.131	1.12	0.131	11.59
	0.2	0.255	14.27	0.372	4.69	0.423	1.10	0.452	11.21
	0.3	0.430	14.28	0.609	4.70	0.669	1.08	0.693	11.14
	0.4	0.593	13.944	0.793	4.54	0.846	1.03	0.865	10.736
Bivariate	0.01	0.302	11.89	0.335	7.47	0.352	4.88	0.35	8.25
Gamma	0.025	0.666	11.734	0.709	7.42	0.718	4.84	0.733	7.98
	0.05	0.714	12.67	0.738	7.50	0.758	4.62	0.776	8.93
	0.1	0.955	13.09	0.972	7.36	0.978	4.25	0.982	9.25
	0.2	0.995	13.00	0.996	6.86	0.998	3.68	0.999	9.17
	0.3	0.998	12.47	1	6.67	1	3.59	1	8.65
	0.4	1	12.18	1	6.30	1	3.37	1	8.27

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