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Table 6 Best interaction models identified by MR-MDR, multi-CMDR and multi-QMDR

From: Spatial rank-based multifactor dimensionality reduction to detect gene–gene interactions for multivariate phenotypes

Method

First order

Second order

rs ID

CVC

Test Score

p-value

rs ID

CVC

Test Score

p-value

MR-MDR

rs41476549

5

5.05

0.022

rs41476549, rs1117105

2

6.23

0.015

rs790410

1

6.20

0.003

rs790410, rs961413

1

7.31

0.002

rs16862782

1

5.17

0.015

rs11250624, rs17168600

1

7.21

0.003

rs1348637

1

4.99

0.027

rs41476549, rs790410

1

7.01

0.004

rs291877

1

4.94

0.029

rs17168600, rs41476549

1

6.94

0.004

rs17168600

1

4.39

0.064

rs291877, rs790410

1

6.48

0.013

rs7706475, rs41476549

1

6.20

0.016

rs4686914, rs16992376

1

3.38

0.583

rs17586294, rs7016675

1

3.33

0.601

Multi-CMDR

rs1348637

3

1.32

0.062

rs790410, rs961413

2

1.87

0.003

rs16862821

2

1.23

0.110

rs291877, rs7612956

1

1.93

0.002

rs790410

1

1.57

0.012

rs291877, rs17168600

1

1.73

0.007

rs291877

1

1.54

0.015

rs291877, rs961413

1

1.65

0.012

rs4686914

1

1.45

0.027

rs291877, rs17643945

1

1.45

0.038

rs41476549

1

1.17

0.162

rs17142042, rs1160759

1

1.19

0.002

rs17142042

1

0.89

0.538

rs17643945, rs291877

1

1.45

0.038

rs12337165, rs9958995

1

1.01

0.364

rs9812308, rs12860002

1

0.78

0.733

Multi-QMDR_FPC

rs10517358

6

27.05

 < 0.001

rs17014894, rs10517358

6

51.05

 < 0.001

rs7265852

3

2.86

0.002

rs41457747, rs10517358

2

27.58

 < 0.001

rs17014894

1

24.17

 < 0.001

rs41457747, rs17014894

1

24.35

 < 0.001

rs1631834, rs10517358

1

2.97

 < 0.014

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BMC Bioinformatics

ISSN: 1471-2105

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