Fig. 5

Multiattractor systems in EMT and TRRUST2 networks. a EMT subnetwork containing the colored edges from Fig. 2g. b Scatter-line plot of tristable (background, blue) and tetrastable (foreground, orange) systems found in this subnetwork, plotted on axes of ZEB1 and miR-34a concentration. Tristable systems are much more common; only 100 are shown. Each line again represents one system that gave rise to multiple distinct attractors. Each point connected by a line shows the location of a distinct attractor in concentration space. c Heatmap of multistable systems found in the same EMT subnetwork. Attractors within 0.5 units are folded together, only 100 tristable systems are shown, and only 10 tristable systems are traced by arc connectors. d A small mixed-sign high-feedback TP53-containing TRRUST2 subnetwork capable of generating oscillatory attractors. Dashed cycle, negative feedback loop. e Scatter-line plot of bistable or oscillation-containing systems found in the subnetwork shown in c. Oscillatory attractors are shown as a thick dashed line tracing the orbit. Most oscillators are the only attractor in their system. f Biclustered heatmap of the same systems. Oscillatory attractors are shown as gradients instead of solid-colored cells