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Table 3 Results of Circall, CIRI2, Mapsplice, CIRCexplorer and find_circ in the simulated datasets

From: Circall: fast and accurate methodology for discovery of circular RNAs from paired-end RNA-sequencing data

Dataset

Method

# detected circRNA

#False positive

#true circRNA

Sensitivity (%)

Precision (%)

F1

Mix1

Circall

5644

10

5634

90.06

99.82

0.95

CIRI2

5661

15

5646

90.25

99.74

0.95

Mapsplice

4822

2

4820

77.05

99.96

0.87

CIRCexplorer

5631

25

5606

89.61

99.56

0.94

Mix2

Circall

6503

869

5634

90.06

86.64

0.88

CIRI2

6531

885

5646

90.25

86.45

0.88

Mapsplice

5603

782

4821

77.06

86.04

0.81

CIRCexplorer

6522

917

5605

89.59

85.94

0.88

Mix3

Circall

5940

79

5861

93.69

98.67

0.96

CIRI2

6062

163

5912

94.29

97.31

0.96

Mapsplice

5148

1

5130

82.27

99.98

0.90

CIRCexplorer

5414

39

5372

85.92

99.28

0.92

find circ

5729

184

5545

88.63

96.79

0.93

  1. The values with bold text in the F1 column indicate the top-performing methods in the dataset