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Fig. 1 | BMC Bioinformatics

Fig. 1

From: MSA: reproducible mutational signature attribution with confidence based on simulations

Fig. 1

Attribution with a classic and b parametric bootstrap. Confidence intervals are derived as [2.5%, 97.5%] percentiles of the resulting bootstrap activities, applied to simulated data with COSMIC signatures SBS 1, 5, 22 and 40, without noise. Point estimates of NNLS attribution (red dots) almost perfectly coincide with the generated true values (green dots) in such noiseless scenario

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