Table 3 The number of variants and measured concordance of the fathmm-MKL (non-coding), fathmm-MKL (coding), and CADD scores for the different ClinVar releases
From: VPMBench: a test bench for variant prioritization methods
Year | #Variants | fathmm-MKL (non-coding) | fathmm-MKL (coding) | CADD |
|---|---|---|---|---|
2012 | 10,295 | 9,235 (89.7%) | 9,099 (88.4%) | 9,651 (93.7%) |
2013 | 10,484 | 9,579 (91.4%) | 9,402 (89.7%) | 9,978 (95.2%) |
2014 | 14,960 | 12,288 (82.1%) | 12,723 (84.2%) | 13,716 (91.7%) |
2015 | 18,725 | 14,981 (80.0%) | 15,762 (84.2%) | 17,159 (91.6%) |
2016 | 24,449 | 19,188 (78.5%) | 20,416 (83.5%) | 22,183 (90.7%) |
2017 | 31,726 | 25,910 (81.7%) | 27,263 (85.9%) | 29,044 (91.5%) |
2018 | 56,115 | 44,351 (79.0%) | 47,414 (84.5%) | 51,650 (92.0%) |
2019 | 63,354 | 49,907 (78.8%) | 53,362 (84.2%) | 58,297 (92.0%) |
2020 | 111,289 | 76,754 (69.0%) | 87,302 (78.4%) | 98,160 (88.2%) |
2021 | 134,384 | 93,879 (69.9%) | 106,179 (79.0%) | 118,734 (88.4%) |