Fig. 1
From: Exploring cell-specific miRNA regulation with single-cell miRNA-mRNA co-sequencing data
Workflow of CSmiR. For each pseudo-cell, we sample from the original dataset (i.e. the 19 single-cells uniformly with replacement) to generate it. Based on the B bootstrapping datasets (matched miRNA and mRNA expression data in the single-cells of the original dataset and interpolated pseudo-cells), we identify m cell-specific miRNA-mRNA regulatory networks by integrating putative miRNA-mRNA binding information for the real m cells (one miRNA-mRNA regulatory network for one cell). Finally, we conduct downstream analysis with the identified m cell-specific miRNA-mRNA regulatory networks