Fig. 10
From: Non-parametric synergy modeling of chemical compounds with Gaussian processes
Analysis of mutually non-exclusive inhibitors data with Hand-GP (left column, a, c) and MuSyC (right column, b, d) models. Estimated effect with the original Median Effect model analysis are shown at the bottom plot. Top row shows the fitted slices of the surfaces along the diagonal. For Hand-GP this is a fit to the non-parametric GP model; for MuSyC a fit to the parametric MuSyC model. Corresponding null models are in grey and regular models in purple. The middle row shows the difference between predicted effects by regular and null models. Estimated synergy effect is shown in green and antagonism in red. Note that confidence intervals are indicated for the HandGP model but are so small as to be almost invisible. Bottom panel, e, shows the combination index reproduced from [20]