Fig. 5
From: Non-parametric synergy modeling of chemical compounds with Gaussian processes
Analysis of Loewe synergy simulated data with Hand-GP (left column, a, c, e, g) and MuSyC (right column, b, d, f, h) models. Top row (a, b) shows the fitted response surfaces. For Hand-GP this is a fit to the non-parametric GP model; for MuSyC a fit to the parametric MuSyC model. The second row (c, d) shows the null reference models. For Hand-GP this is the Hand construction derived from the fitted monotherapeutic responses from the top row; for MuSyC a fit to a constrained MuSyC model. The third row (e, f) shows the synergistic effect surfaces as the difference between the first and second row. The bottom row (g, h) shows the residuals, the difference between the data and the fits from the top row