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Fig. 8 | BMC Bioinformatics

Fig. 8

From: Non-parametric synergy modeling of chemical compounds with Gaussian processes

Fig. 8

Analysis of mutually exclusive inhibitors data with Hand-GP (left column, a, c) and MuSyC (right column, b, d) models. Estimated effect with the original Median Effect model analysis is shown in the bottom plot, e. Top row (a, b) shows fitted slices of the surfaces along the diagonal (in grey) and the null reference models along the same diagonal (in purple). The middle row (c, d) shows the difference between the regular and null models, plotted as a function of fitted fractional effect (inverse of the purple curve in top panels). Estimated synergy is shown in green and antagonism in red. Note that confidence intervals are indicated for the HandGP model but are so small as to be almost invisible. Bottom panel (e) shows the combination index reproduced from [20]

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