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Table 3 Performance comparisons for the methods before and after integrating with hand-crafted biological features (take Spearman correlation coefficient as evaluation index)

From: AttCRISPR: a spacetime interpretable model for prediction of sgRNA on-target activity

Method

WT-SpCas9

eSpCas9(1.1)

SpCas9-HF1

Mean

SD (× 10–3)

Mean

SD (× 10–3)

Mean

SD (× 10–3)

RNN*

0.856

3.33

0.849

5.00

0.851

4.11

EnAC

0.868

2.66

0.859

4.66

0.862

3.19

DeepHF*

0.867

2.37

0.862

4.24

0.860

3.21

StAC

0.872

2.55

0.867

3.71

0.867

2.65

  1. The method with superscript of * and # have been reported respectively [15, 17]. In the tables, we use the results reported in the relevant papers as the performance of the method directly
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BMC Bioinformatics

ISSN: 1471-2105

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