Fig. 5

Optimized yeast and rabbit ribosomal protein networks. a Saccharomyces cerevisiae network, b Oryctolagus cuniculus network built at a contact threshold (\(d_t\)) of 12 Å between amino acid residues. The network layout is Edge-weighted Spring-Embedded. The weights of edges correspond to the number of contacts between two rProteins and in that sense are proportional to the transit probability defined as the main influence during \({\text{COSNet}}_i\) random walk. A larger node size corresponds to a larger node degree. Nodes belonging to the 60S large subunit (LSU) have been colored blue and nodes belonging to the 40S small subunit (SSU) have been colored yellow. Note that there are three conserved/sampled interface pathways between rProteins from the two subunits (Table 3). The network representations have been created in Cytoscape [34]