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Table 2 Depicting the sensitivity and specificity analyses of STRIDE compared to PFAM# and TIGRFAM# using 3D7^

From: STRIDE: a command-line HMM-based identifier and sub-classifier of Plasmodium falciparum RIFIN and STEVOR variant surface antigen families

   RIFIN (185) Non-RIFIN Predictive value   STEVOR (43) Non-STEVOR Predictive value
STRIDE Called +  182 0 100% Called +  38 0 100%
  Called − 3 5363 100% Called − 5 5505 99.9%
   98.4% 100%    88.3% 100%  
PFAM Called +  178 0 99% Called +  38 0 100%
  Called − 7 5363 99.8% Called − 5 5505 99.9%
   96.2% 99.9%    88.3% 100%  
TIGRFAM Called +  177 0 100% Called +  38 0 100%
  Called − 8 5363 99.8% Called − 5 5505 99.9%
   95.70% 100%    88.3% 100%  
  1. #We made comparisons across tools using the same parameters as STRIDE
  2. ^The curated 3D7 reference genome served as a gold standard. There are a total of 5548 sequences in the P. falciparum 3D7 reference, where 182 sequences are annotated as RIFINs and 43 sequences are annotated as STEVORs (includes 27 RIFIN and 10 STEVOR pseudogenes). Unlike PFAM and TIGRFAM, STRIDE was not trained with the entire 3D7 RIFIN and STEVOR repertoire (Fig. 2). The bolded text illustrates the sensitivity of each program; all three tools had 100% specificity