Fig. 1

Bacterial population predicted by the extended vCOMBAT model over time. The three diagrams display the bacterial population with different simulated treatment length and dosing strategies when using Rifampicin in TB patients. The model-parameter values are taken from Table 1. The resulting graphs show that (a) with a single dose of Rifampicin (600 mg), the bacteria population decreases and then regrows approximately after day two and (b) with repeated doses of Rifampicin daily, the bacterial population keeps being decreased through 4 days and (c) the bacterial population over the first 30 min of the simulated treatment for both dosing strategies in (a) and (b). The x-axis shows the simulated treatment length in hours or minutes. The y-axis shows the resulting bacterial population over the treatment time. The percent.bound legends representing the sub-populations which have from 0 to 100% of bound targets are depicted by different colors displayed in (d)