Fig. 5

Interactive web-based tool vCOMBAT for visualizing bacterial population, antibiotic concentration, and complex bound target over simulated treatment length. This figure shows a result page of vCOMBAT displaying the bacterial population when using Rifampicin to treat TB with a single dose. The input parameters are from Table 1. The results (the graph in the right) are displayed in the logarithm scale based on model-parameter values provided by users (the panel in the left). Users can provide the desired parameter values by entering their data to the panel on the left. Users also provide measured/external antibiotic concentrations by entering data to the field “Drug Concentration over Time”. In the resulting graph, the x-axis shows the simulated treatment length in hours. The y-axis shows the resulting bacterial population in the logarithm scale over the treatment time. There are 101 stacked area in this graph representing the bacterial population \(L_{x}\) (x represents the percentage of bound targets varies from 0 to 100). The darker color depicts the higher value of x. The web-based tool also provides the output data (\(L_{x}\) values for each hour during the simulated treatment length)