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Table 2 Model-parameter values of the three test cases used for model validation and performance analysis

From: vCOMBAT: a novel tool to create and visualize a computational model of bacterial antibiotic target-binding

Parameter

Testcase 1

Testcase 2

Testcase 3

Starting population

\(1e^{6}\)

\(1e^{6}\)

\(1e^{6}\)

Initial antibiotic level (mol/cell)

\(1e^{3}\)

\(1e^{3}\)

\(1e^{6}\)

Simulated treatment length (s)

86400

86400

86400

Target molecules

100

100

100

Maximum kill rate

0

0.001

0.001

Killing threshold

50

60

60

Replication threshold

50

50

50

Maximum replication rate

0

0.00025

0.00025

Binding rate

1

1

1

Unbinding rate

0.01

0.01

0.01

Drug Molecular Weight

555.5

555.5

555.5

Carrying capacity

\(1e^{9}\)

\(1e^{9}\)

\(1e^{9}\)

Intracellular volume

\(1e^{-15}\)

\(1e^{-15}\)

\(1e^{-15}\)