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Fig. 1 | BMC Bioinformatics

Fig. 1

From: ECCsplorer: a pipeline to detect extrachromosomal circular DNA (eccDNA) from next-generation sequencing data

Fig. 1

Overview of the ECCsplorer pipeline (a) and it’s output (b, c). a Our pipeline consists of four main modules: one for the data preparation module and three for the analysis modules. The execution of the different modules depends on the given input data. Thick grey arrows represent multi-step bioinformatics computation processes, thin black arrows show data transfer. Semi-artificial circSeq and control data were simulated from a circularized retrotransposon and a random reference sequence to illustrate a typical pipeline output. A more detailed overview of the ECCsplorer pipeline is available in Additional file 1: Figure S1. b Mapping against the reference sequence revealed an eccDNA candidate region. c The comparative read clustering identified 13 clusters containing potential eccDNA candidates. d The comparative module links the retrotransposon candidate region from the mapping module to all 13 clusters from the clustering module

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