Table 2 Mann Whitney U statistic and p-values calculated from Mann-Whitney U test to determine a significant difference in average AUROCs and PRCs of signature similarity matrix rankings of the unweighted drug set created from DrugRIF and randomly shuffled predictions across libraries of drug-related terms that were queried using DrugShot
From: DrugShot: querying biomedical search terms to retrieve prioritized lists of small molecules
AUROC evaluation | PRC Evaluation | |||
|---|---|---|---|---|
Library | U-statistic | p-value | U-statistic | p-value |
SIDER side effects (1298 terms) | 1,191,630 | 6.79E−240 | 771,508 | 1.37E−11 |
SIDER indications (835 terms) | 558,470 | 1.39E−154 | 388,449 | 2.51E−15 |
Drug repurposing hub MoA (154 terms) | 18,728 | 2.75E−32 | 14,061 | 1.74E−07 |
GO biological processes (1364 terms) | 674,733 | 5.06E−230 | 505,036 | 6.32E−53 |