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Table 3 Terms with highest performing AUROC values from the signature similarity matrix benchmark, each with a link to an Appyter instance

From: DrugShot: querying biomedical search terms to retrieve prioritized lists of small molecules

Term

AUROC

Library

DrugShot Appyter instance URLs

mTOR inhibitor

0.9042

Drug Repurposing Hub mechanism of action

https://appyters.maayanlab.cloud/DrugShot/9ba88a051c155dc0adcea183c52aebda3265e909/

AKT inhibitor

0.8953

Drug Repurposing Hub mechanism of action

https://appyters.maayanlab.cloud/DrugShot/d17a38351796e759557014ac14a6ef0098404d71/

Thymidylate synthase inhibitor

0.8821

Drug Repurposing Hub mechanism of action

https://appyters.maayanlab.cloud/DrugShot/4bac8288bbb11786b6cedb7aaae685e7a7957236/

PI3K inhibitor

0.8806

Drug Repurposing Hub mechanism of action

https://appyters.maayanlab.cloud/DrugShot/afab724e5461e367bd061684d4d1ecc7b96e4c13/

HDAC inhibitor

0.8785

Drug Repurposing Hub mechanism of action

https://appyters.maayanlab.cloud/DrugShot/61ebfcc11fe370a574041d9dfea7ab1f2d8a191e/

Small cell lung cancer

0.8683

SIDER indications

https://appyters.maayanlab.cloud/DrugShot/84d1f4fb47842d045d16c88801e421dfffee08f7/

Mitotic cytokinesis

0.8631

Gene Ontology

https://appyters.maayanlab.cloud/DrugShot/5ebe7c287b81769177694bfac65b3f6e72483961/

Doxorubicin metabolic process

0.8622

Gene Ontology

https://appyters.maayanlab.cloud/DrugShot/98e8263b587a47383e9d05381c0ebb4a67af78be/

Positive regulation of lymphoc. proliferation

0.8567

Gene Ontology

https://appyters.maayanlab.cloud/DrugShot/240cdbca4a8e45b83e55ffcdb1c1a2617c5da908/

Activation of MAPKKK activity

0.8554

Gene Ontology

https://appyters.maayanlab.cloud/DrugShot/295c6c5654acb00f8dcd493a0b5143215b3374ec/

Positive regulation of cell cycle arrest

0.8534

Gene Ontology

https://appyters.maayanlab.cloud/DrugShot/63483f95a344da35eb501b8b4da5b9602e88ad83/

Malignant glioma

0.84823

SIDER indications

https://appyters.maayanlab.cloud/DrugShot/98790408cbcbaa0cc86d969cff3871e699c115ef/

Pancytopenia

0.8448

SIDER indications

https://appyters.maayanlab.cloud/DrugShot/117f31c00cef90ee68cebe3a3157a7748f82fad3/

Non-small cell lung cancer

0.84403

SIDER indications

https://appyters.maayanlab.cloud/DrugShot/60c28aff5fc5a731dae5aae5c77d17dec7d9e1a4/

Cervix carcinoma

0.844006

SIDER indications

https://appyters.maayanlab.cloud/DrugShot/2a58a9b18f1a0f67adab59d46129a8b81ad8bf3f/

Gastrointestinal carcinoma

0.8417

SIDER side effects

https://appyters.maayanlab.cloud/DrugShot/f96cce428065905c66c0ec59444316dcae44d717/

Impaired healing

0.8377

SIDER side effects

https://appyters.maayanlab.cloud/DrugShot/d6f0c132ceb3cb31301a64f2f8252554f3f2dd48/

Myeloid leukaemia

0.8361

SIDER side effects

https://appyters.maayanlab.cloud/DrugShot/c56dc625efee9bf409bf01429981bf0ee500ca4b/

Gastrointestinal toxicity

0.8348

SIDER side effects

https://appyters.maayanlab.cloud/DrugShot/9ec18f5d1415f37783c406a31c89740fc268f177/