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Fig. 1 | BMC Bioinformatics

Fig. 1

From: TADreg: a versatile regression framework for TAD identification, differential analysis and rearranged 3D genome prediction

Fig. 1

Illustration of the sparse insulation model (SIM) and identification of TAD borders and facilitators. A Schema representing the insulation effects modeled by SIM on long-range contacts between two bins (two loci), such as between an enhancer and a promoter. B Hi-C heatmap from IMR90 cells at 25 kb resolution. C Insulation score. D SIM beta (no penalty). E SIM beta (L0 penalty). F CTCF enrichment profile depending on border strength (beta). G DNA binding protein enrichment compared to background for several proteins at TAD borders identified by our model (negative betas) depending on protein abundance. H DNA binding protein enrichment compared to background for several proteins at TAD facilitators identified by our model (positive betas) depending on protein abundance

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