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Fig. 3 | BMC Bioinformatics

Fig. 3

From: TADreg: a versatile regression framework for TAD identification, differential analysis and rearranged 3D genome prediction

Fig. 3

Differential analysis of TAD borders with the Differential Insulation Model (DIM). A Hi-C heatmap in mouse embryonic stem (ES) cells. B Corresponding Hi-C heatmap in cortical neuron (CN) cells. C Identification of TAD borders in ES cells (spase insulation model beta is plotted). D Identification of TAD borders in CN cells (spase insulation model beta is plotted). E Identification of differential TAD borders (DIM beta is plotted). For each beta, an adjusted p-value is plotted to show significance. F Number of cell-type specific borders, for varying differential border strengths. G Absolute value of beta between CN specific borders and ES specific borders. H CTCF enrichment at CN specific borders compared to ES specific borders. I DNA-binding protein motif enrichment (fold-change) at CN specific borders. J DNA-binding protein motif enrichment (fold-change) at ES specific borders

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BMC Bioinformatics

ISSN: 1471-2105

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