Fig. 7

Application of abc4pwm in TF binding motif prediction by using either ChIP-seq data or gene expression profiles. A Application of abc4pwm in ESR1 CHIP-seq data in MCF7 cells, where the predicted novo motif L20_1 is similar to known-ESR1-1,2,3 motifs (similarity score = 0.89) based on motif search module of abc4pwm. B Application of abc4pwm in RNA-seq data of TP-53 knockout experiment, the top enriched novo motif L10_1 in promoters of differentially expressed genes is similar to known-TP53 motifs TP53_6 and TP53_7 (similarity score = 0.85). The left panel is the motif logo of TFs, the right panel shows the output of motif similar scores from abc4pwm searching module