Fig. 4

Enrichment of mutations in different motifs and transcripts. a Investigating the mutations in tri-nucleotide motifs of genes that become significant in multiple subtypes revealed a motif context specificity of mutations in each subtype. For example, TP53 becomes a significant gene in both SC1 and SC5. However, the preference tri-nucleotide motif of mutations in SC1 is CT-G.G, while in SC5, it is CT-T.G. b Our analysis also shows that for some of the candidate genes, the mutations are enriched in a specific transcript of the gene