Computationally repurposing drugs for breast cancer subtypes using a network-based approach

BMC Bioinformatics

Table 12 Rank comparison among the top 30 drugs across all 10 breast cancer subtypes

Overall Rank	Drugs	S1	S2	S3	S4	S5	S6	S7	S8	S9	S10	Median
1	Ruxolitinib	1	3	2	43	1	1	2	2	2	1	2
2	Tranilast	4	12	11	193	7	11	4	43	32	4	11
3	Rupatadine	22	44	6	1	31	2	15	11	1	51	13
4	Ribavirin	2	10	7	2	9	20	60	66	21	17	13.5
5	Deferiprone	3	14	3	15	27	4	20	6	183	20	14.5
6	Etofylline-Clofibrate	16	29	9	20	15	45	5	15	45	9	15.5
7	Fingolimod	36	6	58	137	16	9	3	109	20	13	18
8	ICI-185282	61	4	21	46	17	7	14	39	35	3	19
9	PF-04217903	10	25	16	398	10	40	10	107	25	10	20.5
10	Raloxifene	30	43	26	7	25	31	8	4	3	75	25.5
11	EDTA	13	55	10	8	18	127	112	196	38	6	28
12	Amiprilose	23	46	57	13	42	10	61	14	7	34	28.5
13	Bafilomycin A1	101	28	33	6	21	34	21	30	191	5	29
14	Dexamethasone	27	21	91	171	32	68	23	87	17	23	29.5
15	Dofequidar	11	88	24	14	106	29	104	29	31	56	30
16	MK-1775	14	49	12	61	24	37	13	46	41	7	30.5
17	TG-100801	121	50	44	60	6	17	11	18	8	53	31
18	Swainsonine	15	58	17	34	90	48	63	28	23	27	31
19	Raclopride	24	54	13	4	30	36	19	71	137	36	33
20	L-690330	37	7	38	35	61	32	12	314	5	133	36
21	Phentermine	57	22	43	57	135	5	36	12	26	55	39.5
22	PHA-767491	64	8	8	153	13	257	9	325	379	15	39.5
23	PD-173074	59	18	42	108	37	27	17	356	15	142	39.5
24	Lidocaine	122	17	103	212	12	88	25	17	51	30	40.5
25	Mibampator	98	15	20	22	93	12	46	60	85	37	41.5
26	PD-153035	26	108	214	18	35	128	33	47	235	39	43
27	AKT-inhibitor-1-2	21	24	40	110	48	57	34	150	282	22	44
28	Maraviroc	41	77	25	9	41	3	48	149	132	415	44.5
29	SDZ-NKT-343	104	5	65	203	5	39	6	51	241	24	45
30	Clomipramine	48	198	37	177	22	46	44	155	153	32	47

ISSN: 1471-2105