Computationally repurposing drugs for breast cancer subtypes using a network-based approach

BMC Bioinformatics

Table 6 Top 20 drugs corresponding to subtype 5

Rank	Drug	Dosage (μm)	Treatment time (h)	Score	Drug type	References
1	Ruxolitinib	10	24	− 0.93	Approved	[51, 52]
2	AMG-837	0.04	24	− 0.83	Experimental
3	Citrulline	0.04	24	− 0.82	Investigational
4	Loperamide	10	24	− 0.77	Approved	[106]
5	SDZ-NKT-343	10	24	− 0.74	Experimental
6	TG-100801	0.04	24	− 0.72	Investigational
7	Tranilast	0.04	24	− 0.72	Investigational	[68]
8	Bisoprolol	10	24	− 0.71	Approved	[107]
9	Ribavirin	10	24	− 0.7	Approved	[65]
10	PF-04217903	0.04	24	− 0.7	Investigational
11	Sirolimus	0.04	24	− 0.69	Approved	[71, 72]
12	Lidocaine	0.04	24	− 0.69	Approved	[86, 87]
13	PHA-767491	10	24	− 0.68	Experimental	[83]
14	WZ-4-145	0.04	3	− 0.68	Experimental
15	Etofylline-Clofibrate	10	24	− 0.67	Approved
16	Fingolimod	0.04	24	− 0.67	Approved	[82]
17	ICI-185,282	0.04	24	− 0.67	Experimental
18	EDTA	10	24	− 0.67	Approved	[93]
19	Labetalol	0.04	24	− 0.66	Approved
20	MF-101	10	24	− 0.66	Experimental

ISSN: 1471-2105